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4hw3
From Proteopedia
(Difference between revisions)
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==Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design== | ==Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design== | ||
| - | <StructureSection load='4hw3' size='340' side='right' caption='[[4hw3]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='4hw3' size='340' side='right'caption='[[4hw3]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4hw3]] is a 12 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4hw3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HW3 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19G:3-[3-(4-CHLORO-3,5-DIMETHYLPHENOXY)PROPYL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>19G</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=19G:3-[3-(4-CHLORO-3,5-DIMETHYLPHENOXY)PROPYL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>19G</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hw3 OCA], [https://pdbe.org/4hw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hw3 RCSB], [https://www.ebi.ac.uk/pdbsum/4hw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hw3 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4hw3" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4hw3" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Zhao B]] |
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| - | + | ||
| - | + | ||
Revision as of 08:19, 9 November 2022
Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design
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