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| | ==Crystal structure of ATBAG2== | | ==Crystal structure of ATBAG2== |
| - | <StructureSection load='4hwd' size='340' side='right' caption='[[4hwd]], [[Resolution|resolution]] 2.31Å' scene=''> | + | <StructureSection load='4hwd' size='340' side='right'caption='[[4hwd]], [[Resolution|resolution]] 2.31Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4hwd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HWD FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4hwd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HWD FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hwc|4hwc]], [[4hwf|4hwf]], [[4hwh|4hwh]], [[4hwi|4hwi]]</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwd OCA], [https://pdbe.org/4hwd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hwd RCSB], [https://www.ebi.ac.uk/pdbsum/4hwd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwd ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">At5g62100, BAG2, MTG10.13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwd OCA], [http://pdbe.org/4hwd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hwd RCSB], [http://www.ebi.ac.uk/pdbsum/4hwd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwd ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/BAG2_ARATH BAG2_ARATH]] Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses (By similarity). | + | [https://www.uniprot.org/uniprot/BAG2_ARATH BAG2_ARATH] Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses (By similarity). |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </div> | | </div> |
| | <div class="pdbe-citations 4hwd" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 4hwd" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[BAG family proteins 3D structures|BAG family proteins 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Arath]] | + | [[Category: Arabidopsis thaliana]] |
| - | [[Category: Fang, S]] | + | [[Category: Large Structures]] |
| - | [[Category: Shen, Y]] | + | [[Category: Fang S]] |
| - | [[Category: Apoptosis]] | + | [[Category: Shen Y]] |
| - | [[Category: Co-chaperone]]
| + | |
| - | [[Category: Three helix bundle]]
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| Structural highlights
Function
BAG2_ARATH Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses (By similarity).
Publication Abstract from PubMed
The recently identified plant Bcl-2-associated athanogene (BAG) family plays an extensive role in plant programmed cell death (PCD) processes ranging from growth and development to stress responses and even cell death. In the Arabidopsis thaliana BAG (AtBAG) protein family, four members (AtBAG1-4) have a domain organization similar to that of mammalian BAG proteins. Here, crystal structures of the BAG domains (BDs) of AtBAG1-4 have been determined; they have high homology and adopt a structure comprising three short parallel alpha-helices, similar to some mammalian BAG proteins. The crystal structure of a complex of the AtBAG1 ubiquitin-like domain and BAG domain (UBD) with the Hsc70 nucleotide-binding domain (NBD) was also determined. The binding of the AtBAG1 BD to the Hsc70 NBD induces conformational change of the Hsc70 NBD to the open state and reduces the affinity of the NBD for ADP. In vivo studies showed that bag2-1 mutant plants are larger than wild-type plants when growing under normal conditions, indicating that the AtBAG proteins might regulate plant PCD and confer tolerance to stresses in plants. These structural and functional analyses indicate that the AtBAG proteins function as nucleotide-exchange factors for Hsp70/Hsc70 in A. thaliana and that the mechanism of regulation of chaperone-mediated protein folding is conserved in plants.
Structural insight into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana.,Fang S, Li L, Cui B, Men S, Shen Y, Yang X Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):934-45. doi:, 10.1107/S0907444913003624. Epub 2013 May 2. PMID:23695238[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Fang S, Li L, Cui B, Men S, Shen Y, Yang X. Structural insight into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana. Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):934-45. doi:, 10.1107/S0907444913003624. Epub 2013 May 2. PMID:23695238 doi:10.1107/S0907444913003624
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