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4hza
From Proteopedia
(Difference between revisions)
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==Crystal Structure of the Immunoglobulin variable domain of Nectin-2 in monoclinic form== | ==Crystal Structure of the Immunoglobulin variable domain of Nectin-2 in monoclinic form== | ||
| - | <StructureSection load='4hza' size='340' side='right' caption='[[4hza]], [[Resolution|resolution]] 1.70Å' scene=''> | + | <StructureSection load='4hza' size='340' side='right'caption='[[4hza]], [[Resolution|resolution]] 1.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4hza]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4hza]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HZA FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hza OCA], [https://pdbe.org/4hza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hza RCSB], [https://www.ebi.ac.uk/pdbsum/4hza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hza ProSAT]</span></td></tr> |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/NECT2_HUMAN NECT2_HUMAN] Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).<ref>PMID:26755705</ref> <ref>PMID:9657005</ref> (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).<ref>PMID:11602758</ref> <ref>PMID:9657005</ref> |
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| + | ==See Also== | ||
| + | *[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Almo SC]] |
| - | + | [[Category: Nathenson SG]] | |
| - | [[Category: Nathenson | + | [[Category: Ramagopal UA]] |
| - | [[Category: Ramagopal | + | [[Category: Samanta D]] |
| - | [[Category: Samanta | + | |
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Revision as of 08:29, 9 November 2022
Crystal Structure of the Immunoglobulin variable domain of Nectin-2 in monoclinic form
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