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4i16

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==Crystal structure of CARMA1 CARD==
==Crystal structure of CARMA1 CARD==
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<StructureSection load='4i16' size='340' side='right' caption='[[4i16]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='4i16' size='340' side='right'caption='[[4i16]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4i16]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I16 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I16 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4i16]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I16 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I16 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Card11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i16 OCA], [https://pdbe.org/4i16 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i16 RCSB], [https://www.ebi.ac.uk/pdbsum/4i16 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i16 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i16 OCA], [http://pdbe.org/4i16 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i16 RCSB], [http://www.ebi.ac.uk/pdbsum/4i16 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i16 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CAR11_MOUSE CAR11_MOUSE]] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 (By similarity).
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[https://www.uniprot.org/uniprot/CAR11_MOUSE CAR11_MOUSE] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Li, S]]
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[[Category: Mus musculus]]
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[[Category: Shen, Y]]
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[[Category: Li S]]
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[[Category: Yang, X]]
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[[Category: Shen Y]]
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[[Category: Bcl10 and malt1 binding]]
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[[Category: Yang X]]
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[[Category: Cbm complex]]
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[[Category: Helix bundle]]
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[[Category: Phosphorylation]]
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[[Category: Scaffold protein]]
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[[Category: Signaling protein]]
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Revision as of 08:33, 9 November 2022

Crystal structure of CARMA1 CARD

PDB ID 4i16

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