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4i1s

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Current revision (08:34, 9 November 2022) (edit) (undo)
 
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==Melanoma differentiation associated protein-5 Helicase domain complex with inhibitor Non-structural protein V==
==Melanoma differentiation associated protein-5 Helicase domain complex with inhibitor Non-structural protein V==
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<StructureSection load='4i1s' size='340' side='right' caption='[[4i1s]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
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<StructureSection load='4i1s' size='340' side='right'caption='[[4i1s]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4i1s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig] and [http://en.wikipedia.org/wiki/Piv5 Piv5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I1S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4i1s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_virus_5_(strain_W3) Simian virus 5 (strain W3)] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I1S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1s OCA], [https://pdbe.org/4i1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i1s RCSB], [https://www.ebi.ac.uk/pdbsum/4i1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1s ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MDA5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG]), P/V ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11208 PIV5])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1s OCA], [http://pdbe.org/4i1s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i1s RCSB], [http://www.ebi.ac.uk/pdbsum/4i1s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1s ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/V_SV5 V_SV5]] Blocks host interferon signaling. Induces the ubiquitination and subsequent proteasome-mediated degradation of host STAT1. Acts as an adapter, linking host DDB1-Cullin 4 to STAT2/STAT1 complex. There is an absolute requirement of STAT2 in STAT1 degradation, as V binds specifically to STAT2. Might act as a chaperone keeping the viral nucleoprotein soluble. Interacts with host IFIH1/MDA5 to block its activity in the transduction pathway which leads to the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state.<ref>PMID:15950997</ref>
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[https://www.uniprot.org/uniprot/A7LCX1_PIG A7LCX1_PIG]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pig]]
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[[Category: Large Structures]]
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[[Category: Piv5]]
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[[Category: Sus scrofa]]
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[[Category: Hopfner, K P]]
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[[Category: Hopfner KP]]
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[[Category: Motz, C]]
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[[Category: Motz C]]
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[[Category: Witte, G]]
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[[Category: Witte G]]
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[[Category: Helicase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Sf2-atpase]]
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Current revision

Melanoma differentiation associated protein-5 Helicase domain complex with inhibitor Non-structural protein V

PDB ID 4i1s

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