4i5x

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==Crystal Structure Of AKR1B10 Complexed With NADP+ And Flufenamic acid==
==Crystal Structure Of AKR1B10 Complexed With NADP+ And Flufenamic acid==
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<StructureSection load='4i5x' size='340' side='right' caption='[[4i5x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4i5x' size='340' side='right'caption='[[4i5x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4i5x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I5X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4i5x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I5X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLF:2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO]+BENZOIC+ACID'>FLF</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLF:2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO]+BENZOIC+ACID'>FLF</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gqg|4gqg]], [[4gq0|4gq0]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i5x OCA], [https://pdbe.org/4i5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i5x RCSB], [https://www.ebi.ac.uk/pdbsum/4i5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i5x ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1B10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i5x OCA], [http://pdbe.org/4i5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i5x RCSB], [http://www.ebi.ac.uk/pdbsum/4i5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i5x ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN]] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
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[https://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4i5x" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4i5x" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aldo-keto reductase 3D structures|Aldo-keto reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Chen, S]]
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[[Category: Large Structures]]
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[[Category: Zhai, J]]
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[[Category: Chen S]]
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[[Category: Zhang, H]]
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[[Category: Zhai J]]
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[[Category: Zhang, L]]
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[[Category: Zhang H]]
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[[Category: Zhao, Y]]
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[[Category: Zhang L]]
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[[Category: Zheng, X]]
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[[Category: Zhao Y]]
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[[Category: Aldo-keto reductase]]
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[[Category: Zheng X]]
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[[Category: Oxidoreductase]]
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[[Category: Tim barrel]]
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Revision as of 08:43, 9 November 2022

Crystal Structure Of AKR1B10 Complexed With NADP+ And Flufenamic acid

PDB ID 4i5x

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