Topoisomerases: A Biochemical Overview

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== Disease ==
== Disease ==
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Genetic mutations that directly impair the function of topoisomerases have correlation to autism spectrum disorders (ASDs) and similar neurological disorders. These genetic mutations cause the elongating of particular genes that are correlated to the expression of ASDs. Specifically, Ube3a is one of hundreds of genes that are associated with the development of ASDs in humans when elongated. Inhibitors of TOP1, such as topotecan, have been shown to reduce the expression of the elongated
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Genetic mutations that directly impair the function of topoisomerases have correlation to autism spectrum disorders (ASDs) and similar neurological disorders. These genetic mutations cause the elongating of particular genes that are correlated to the expression of ASDs. Specifically, Ube3a is one of hundreds of genes that are associated with the development of ASDs in humans when elongated.
== Relevance ==
== Relevance ==

Revision as of 20:38, 9 November 2022

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Topoisomerase

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References

  1. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

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