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CAMP-dependent protein kinase 3D structures

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*PKA catalytic subunit binary complex
*PKA catalytic subunit binary complex
-
**[[6c0u]] - hPKA + inhibitor<br />
+
**[[6c0u]], [[7y1g]] - hPKA + inhibitor<br />
**[[3agl]], [[3agm]] – hPKA + bisubstrate inhibitor<br />
**[[3agl]], [[3agm]] – hPKA + bisubstrate inhibitor<br />
**[[3bwj]] - bPKA + bisubstrate inhibitor<br />
**[[3bwj]] - bPKA + bisubstrate inhibitor<br />
**[[1szm]] - bPKA + bisindolymaleimide<br />
**[[1szm]] - bPKA + bisindolymaleimide<br />
**[[3ag9]] - bPKA + inhibitor<br />
**[[3ag9]] - bPKA + inhibitor<br />
 +
**[[7lz4]] – bPKA (mutant) + CMP<br />
**[[5n1f]], [[5n1g]], [[5n1h]], [[5n3g]], [[5n3h]], [[5n3i]], [[5n3j]], [[5n3k]], [[5n3l]], [[5n3m]], [[5n3n]], [[5n3o]], [[5n3p]], [[5n3q]], [[5n3r]], [[5n3s]], [[5n3t]] - haPKA + fragment molecule<br />
**[[5n1f]], [[5n1g]], [[5n1h]], [[5n3g]], [[5n3h]], [[5n3i]], [[5n3j]], [[5n3k]], [[5n3l]], [[5n3m]], [[5n3n]], [[5n3o]], [[5n3p]], [[5n3q]], [[5n3r]], [[5n3s]], [[5n3t]] - haPKA + fragment molecule<br />
**[[6em2]], [[6sq1]] - haPKA + drug<br />
**[[6em2]], [[6sq1]] - haPKA + drug<br />
Line 26: Line 27:
**[[6spy]] - haPKA + pyridine derivative<br />
**[[6spy]] - haPKA + pyridine derivative<br />
**[[6zn0]] - haPKA + nicotinamide derivative<br />
**[[6zn0]] - haPKA + nicotinamide derivative<br />
 +
**[[6z08]], [[7bar]] - haPKA + ligand<br />
**[[4ntt]] – mPKA (mutant) + ADP<br />
**[[4ntt]] – mPKA (mutant) + ADP<br />
**[[1bkx]] – mPKA + adenosine<br />
**[[1bkx]] – mPKA + adenosine<br />
Line 73: Line 75:
**[[6i2a]] - haPKA + RPK153 + drug <br />
**[[6i2a]] - haPKA + RPK153 + drug <br />
**[[6i2c]], [[6i2d]] - haPKA + RPK182 + drug <br />
**[[6i2c]], [[6i2d]] - haPKA + RPK182 + drug <br />
 +
**[[7axt]], [[7axv]], [[7axw]], [[7baq]], [[7bb0]], [[7pid]], [[7pie]], [[7pif]], [[7pig]], [[7pih[[, [[7pns]] - haPKA + PKI + ligand<br />
*PKA catalytic subunit ternary complex with nucleotide
*PKA catalytic subunit ternary complex with nucleotide
Line 82: Line 85:
**[[1atp]] - mPKA + peptide inhibitor + Mn-ATP<br />
**[[1atp]] - mPKA + peptide inhibitor + Mn-ATP<br />
**[[6e21]] - mPKA + peptide inhibitor + ADP<br />
**[[6e21]] - mPKA + peptide inhibitor + ADP<br />
 +
**[[7e0z]], [[7e11]], [[7e12]] - mPKA + PLN peptide + PPNP<br />
**[[6em7]], [[6em6]] - haPKA + peptide inhibitor + inhibitor + ADP<br />
**[[6em7]], [[6em6]] - haPKA + peptide inhibitor + inhibitor + ADP<br />
**[[6eh2]] - haPKA + peptide inhibitor + inhibitor + AMP<br />
**[[6eh2]] - haPKA + peptide inhibitor + inhibitor + AMP<br />
Line 121: Line 125:
**[[3tmh]] - rPKA II-α dimerization-anchoring domain + A-kinase anchoring protein peptide + NHERF-3<br />
**[[3tmh]] - rPKA II-α dimerization-anchoring domain + A-kinase anchoring protein peptide + NHERF-3<br />
 +
**[[8em8]] - PfPKA + peptide + inhibitor <br />
*PKA catalytic and regulatory subunits
*PKA catalytic and regulatory subunits

Revision as of 08:47, 13 November 2022

3D structures of cAMP-dependent protein kinase

Updated on 13-November-2022 {{#tree:id=OrganizedByTopic|openlevels=0|

  • PKA catalytic subunit
    • 6eh0 – haPKA – hamster
    • 1fot - yPKA – yeast
  • PKA catalytic subunit binary complex
  • PKA catalytic subunit binary complex with peptide inhibitor
  • PKA catalytic subunit ternary complex
  • PKA catalytic subunit ternary complex with nucleotide
    • 1q24 - bPKA + peptide inhibitor + Mg-ATP
    • 1jbp - mPKA + detergent + peptide inhibitor + ADP
    • 1rdq - mPKA + peptide inhibitor + ADP + ATP
    • 4o21 - mPKA + peptide inhibitor + ATP-G-S
    • 1atp - mPKA + peptide inhibitor + Mn-ATP
    • 6e21 - mPKA + peptide inhibitor + ADP
    • 7e0z, 7e11, 7e12 - mPKA + PLN peptide + PPNP
    • 6em7, 6em6 - haPKA + peptide inhibitor + inhibitor + ADP
    • 6eh2 - haPKA + peptide inhibitor + inhibitor + AMP
    • 6esa - haPKA + peptide inhibitor + ribose + AMP
    • 6ema - haPKA + peptide inhibitor + inhibitor + ATP
    • 6y8c – haPKA + PKI peptide + ATP
    • 6y05 – haPKA + PKI peptide + Adenine
  • PKA regulatory subunit
    • 4f9k – hPKA I-β
    • 1ne4, 1ne6, 1rl3, 3iia, 1rgs, 4mx3 - bPKA
    • 2ezw - bPKA I-α dimerization-anchoring domain - NMR
    • 3im3 - bPKA I-α dimerization-anchoring domain
    • 3pna - bPKA I-α cAMP-binding domain
    • 1cx4 - rPKA II-β cAMP-binding domain – rat
    • 1r2a - mPKA II dimerization-anchoring domain – NMR
    • 1l6e - mPKA II-α dimerization-anchoring domain – NMR
    • 3of1, 6xqk - yPKA
  • PKA regulatory subunit binary complex
    • 2izx, 2izy, 4zp3 - hPKA II-α + A-kinase anchoring protein peptide
    • 2kyg - hPKA II-α + CBFA2T1
    • 5kjx - hPKA I-α + cAMP
    • 5kjy, 5kjz - hPKA I-α (mutant) + cAMP
    • 3im4, 5hvz - bPKA I-α + A-kinase anchoring protein peptide
    • 4jv4 – bPKA I-α + cAMP analog
    • 3plq - bPKA I-α + cAMP derivative
    • 2hwn - rPKA II-α + A-kinase binding peptide
    • 4jva – rPKA II-β + cAMP analog
    • 2drn, 2h9r - rPKA II-α dimerization-anchoring domain + A-kinase anchoring protein peptide – NMR
    • 5t3n - PfPKA + cAMP derivative – Plasmodium falciparum
    • 5kbf, 5k8s - PfPKA + cAMP
    • 6h4g - PKA (mutant) + cAMP – Trypanosoma brucei
    • 6rsx - PKA + cAMP – Euglena gracilis
  • PKA regulatory subunit ternary complex
    • 3tmh - rPKA II-α dimerization-anchoring domain + A-kinase anchoring protein peptide + NHERF-3
    • 8em8 - PfPKA + peptide + inhibitor
  • PKA catalytic and regulatory subunits

}}

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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