7y4m

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'''Unreleased structure'''
 
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The entry 7y4m is ON HOLD until Paper Publication
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==Crystal structure of Ricin A chain bound with N2-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycyl-L-phenylalanyl-N6-((benzyloxy)carbonyl)-L-lysine==
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<StructureSection load='7y4m' size='340' side='right'caption='[[7y4m]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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Authors: Katakura, S., Goto, M., Ohba, T., Kawata, R., Nagatsu, K., Higashi, S., Matsumoto, K., Kurisu, K., Ohtsuka, K., Saito, R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7y4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y4M FirstGlance]. <br>
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Description: Crystal structure of Ricin A chain bound with N2-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycyl-L-phenylalanyl-N6-((benzyloxy)carbonyl)-L-lysine
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IWQ:(2S)-2-[[(2S)-2-[2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]ethanoylamino]-3-phenyl-propanoyl]amino]-6-(phenylmethoxycarbonylamino)hexanoic+acid'>IWQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y4m OCA], [https://pdbe.org/7y4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y4m RCSB], [https://www.ebi.ac.uk/pdbsum/7y4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y4m ProSAT]</span></td></tr>
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[[Category: Kurisu, K]]
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</table>
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[[Category: Kawata, R]]
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== Function ==
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[[Category: Nagatsu, K]]
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[https://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
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[[Category: Ohtsuka, K]]
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__TOC__
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[[Category: Katakura, S]]
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</StructureSection>
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[[Category: Matsumoto, K]]
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[[Category: Large Structures]]
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[[Category: Ohba, T]]
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[[Category: Ricinus communis]]
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[[Category: Saito, R]]
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[[Category: Goto M]]
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[[Category: Goto, M]]
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[[Category: Higashi S]]
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[[Category: Higashi, S]]
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[[Category: Katakura S]]
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[[Category: Kawata R]]
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[[Category: Kurisu K]]
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[[Category: Matsumoto K]]
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[[Category: Nagatsu K]]
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[[Category: Ohba T]]
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[[Category: Ohtsuka K]]
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[[Category: Saito R]]

Revision as of 20:08, 16 November 2022

Crystal structure of Ricin A chain bound with N2-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycyl-L-phenylalanyl-N6-((benzyloxy)carbonyl)-L-lysine

PDB ID 7y4m

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