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7yzb
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human FoxH1 bound to the TGTGGATT site== | |
| - | + | <StructureSection load='7yzb' size='340' side='right'caption='[[7yzb]], [[Resolution|resolution]] 1.47Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7yzb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YZB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yzb OCA], [https://pdbe.org/7yzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yzb RCSB], [https://www.ebi.ac.uk/pdbsum/7yzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yzb ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/FOXH1_HUMAN FOXH1_HUMAN] Septopreoptic holoprosencephaly;Semilobar holoprosencephaly;Lobar holoprosencephaly;Alobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly;Microform holoprosencephaly. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FOXH1_HUMAN FOXH1_HUMAN] Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).<ref>PMID:9702198</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Macias MJ]] | ||
| + | [[Category: Pluta R]] | ||
Revision as of 20:09, 16 November 2022
Crystal structure of the human FoxH1 bound to the TGTGGATT site
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