4ijd

<StructureSection load='4ijd' size='340' side='right' caption='[[4ijd]], [[Resolution|resolution]] 2.15&Aring;' scene=''>

<table><tr><td colspan='2'>[[4ijd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IJD FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ijd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijd OCA], [http://pdbe.org/4ijd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ijd RCSB], [http://www.ebi.ac.uk/pdbsum/4ijd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijd ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/PRDM9_HUMAN PRDM9_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity).

[[Category: Histone-lysine N-methyltransferase]]

[[Category: Human]]

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Brown, P J]]

[[Category: Dombrovski, L]]

[[Category: Dong, A]]

[[Category: Edwards, A M]]

[[Category: Li, Y]]

[[Category: Structural genomic]]

[[Category: Tempel, W]]

[[Category: Wu, H]]

[[Category: Transferase]]