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4ijp

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Current revision (20:51, 16 November 2022) (edit) (undo)
 
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==Crystal Structure of Human PRPF4B kinase domain in complex with 4-{5-[(2-Chloro-pyridin-4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thiophene-2-carboxylic acid amine==
==Crystal Structure of Human PRPF4B kinase domain in complex with 4-{5-[(2-Chloro-pyridin-4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thiophene-2-carboxylic acid amine==
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<StructureSection load='4ijp' size='340' side='right' caption='[[4ijp]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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<StructureSection load='4ijp' size='340' side='right'caption='[[4ijp]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ijp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IJP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ijp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IJP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1EH:4-(5-{[(2-CHLOROPYRIDIN-4-YL)METHYL]CARBAMOYL}THIOPHEN-2-YL)-1-BENZOTHIOPHENE-2-CARBOXAMIDE'>1EH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1EH:4-(5-{[(2-CHLOROPYRIDIN-4-YL)METHYL]CARBAMOYL}THIOPHEN-2-YL)-1-BENZOTHIOPHENE-2-CARBOXAMIDE'>1EH</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ijp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijp OCA], [https://pdbe.org/4ijp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ijp RCSB], [https://www.ebi.ac.uk/pdbsum/4ijp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijp ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ian|4ian]], [[4ifc|4ifc]], [[4iir|4iir]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIAA0536, PRP4, PRP4H, PRP4K, PRPF4B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ijp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijp OCA], [http://pdbe.org/4ijp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ijp RCSB], [http://www.ebi.ac.uk/pdbsum/4ijp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijp ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PRP4B_HUMAN PRP4B_HUMAN]] Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.
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[https://www.uniprot.org/uniprot/PRP4B_HUMAN PRP4B_HUMAN] Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Chen, X]]
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[[Category: Chen X]]
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[[Category: Haas, K]]
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[[Category: Haas K]]
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[[Category: McLean, L]]
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[[Category: McLean L]]
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[[Category: Mechin, I]]
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[[Category: Mechin I]]
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[[Category: Zhang, Y]]
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[[Category: Zhang Y]]
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[[Category: Kinase]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal Structure of Human PRPF4B kinase domain in complex with 4-{5-[(2-Chloro-pyridin-4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thiophene-2-carboxylic acid amine

PDB ID 4ijp

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OCA

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