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| | ==Crystal structure of A223 C-terminal domain, a structural protein from sulfolobus turreted icosahedral virus (STIV)== | | ==Crystal structure of A223 C-terminal domain, a structural protein from sulfolobus turreted icosahedral virus (STIV)== |
| - | <StructureSection load='4il7' size='340' side='right' caption='[[4il7]], [[Resolution|resolution]] 1.40Å' scene=''> | + | <StructureSection load='4il7' size='340' side='right'caption='[[4il7]], [[Resolution|resolution]] 1.40Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4il7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_turreted_icosahedral_virus Sulfolobus turreted icosahedral virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IL7 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4il7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_turreted_icosahedral_virus_1 Sulfolobus turreted icosahedral virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IL7 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">A223 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269145 Sulfolobus turreted icosahedral virus])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4il7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4il7 OCA], [https://pdbe.org/4il7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4il7 RCSB], [https://www.ebi.ac.uk/pdbsum/4il7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4il7 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4il7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4il7 OCA], [http://pdbe.org/4il7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4il7 RCSB], [http://www.ebi.ac.uk/pdbsum/4il7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4il7 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q6Q0L4_9VIRU Q6Q0L4_9VIRU] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Sulfolobus turreted icosahedral virus]] | + | [[Category: Large Structures]] |
| - | [[Category: Lawrence, C M]] | + | [[Category: Sulfolobus turreted icosahedral virus 1]] |
| - | [[Category: Sendamarai, A K]] | + | [[Category: Lawrence CM]] |
| - | [[Category: C381 and b345]] | + | [[Category: Sendamarai AK]] |
| - | [[Category: Hypothetical protein]]
| + | |
| - | [[Category: Partial jelly roll fold]]
| + | |
| - | [[Category: Viral capsid]]
| + | |
| - | [[Category: Viral protein]]
| + | |
| Structural highlights
Function
Q6Q0L4_9VIRU
Publication Abstract from PubMed
Sulfolobus turreted icosahedral virus (STIV) was isolated in acidic hot springs where it infects the archeon Sulfolobus solfataricus. We determined the STIV structure using near-atomic resolution electron microscopy and X-ray crystallography allowing tracing of structural polypeptide chains and visualization of transmembrane proteins embedded in the viral membrane. We propose that the vertex complexes orchestrate virion assembly by coordinating interactions of the membrane and various protein components involved. STIV shares the same coat subunit and penton base protein folds as some eukaryotic and bacterial viruses, suggesting that they derive from a common ancestor predating the divergence of the three kingdoms of life. One architectural motif (beta-jelly roll fold) forms virtually the entire capsid (distributed in three different gene products), indicating that a single ancestral protein module may have been at the origin of its evolution.
Atomic structure of the 75 MDa extremophile Sulfolobus turreted icosahedral virus determined by CryoEM and X-ray crystallography.,Veesler D, Ng TS, Sendamarai AK, Eilers BJ, Lawrence CM, Lok SM, Young MJ, Johnson JE, Fu CY Proc Natl Acad Sci U S A. 2013 Mar 21. PMID:23520050[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Veesler D, Ng TS, Sendamarai AK, Eilers BJ, Lawrence CM, Lok SM, Young MJ, Johnson JE, Fu CY. Atomic structure of the 75 MDa extremophile Sulfolobus turreted icosahedral virus determined by CryoEM and X-ray crystallography. Proc Natl Acad Sci U S A. 2013 Mar 21. PMID:23520050 doi:http://dx.doi.org/10.1073/pnas.1300601110
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