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4ilc

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==The GLIC pentameric ligand-gated ion channel in complex with sulfates==
==The GLIC pentameric ligand-gated ion channel in complex with sulfates==
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<StructureSection load='4ilc' size='340' side='right' caption='[[4ilc]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
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<StructureSection load='4ilc' size='340' side='right'caption='[[4ilc]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ilc]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovi Glovi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ILC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ilc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus_PCC_7421 Gloeobacter violaceus PCC 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ILC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hfi|4hfi]], [[4il4|4il4]], [[4il9|4il9]], [[4ila|4ila]], [[4ilb|4ilb]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ilc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ilc OCA], [https://pdbe.org/4ilc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ilc RCSB], [https://www.ebi.ac.uk/pdbsum/4ilc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ilc ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">glvI, glr4197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=251221 GLOVI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ilc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ilc OCA], [http://pdbe.org/4ilc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ilc RCSB], [http://www.ebi.ac.uk/pdbsum/4ilc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ilc ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
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[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Ion channels|Ion channels]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glovi]]
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[[Category: Gloeobacter violaceus PCC 7421]]
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[[Category: Corringer, P J]]
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[[Category: Large Structures]]
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[[Category: Delarue, M]]
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[[Category: Corringer PJ]]
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[[Category: Malherbe, L]]
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[[Category: Delarue M]]
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[[Category: Sauguet, L]]
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[[Category: Malherbe L]]
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[[Category: Ion channel]]
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[[Category: Sauguet L]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Pentameric ligand-gated ion channel]]
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[[Category: Transport protein]]
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Revision as of 20:54, 16 November 2022

The GLIC pentameric ligand-gated ion channel in complex with sulfates

PDB ID 4ilc

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