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| | ==Human Histidine Triad Nucleotide Binding Protein 2== | | ==Human Histidine Triad Nucleotide Binding Protein 2== |
| - | <StructureSection load='4inc' size='340' side='right' caption='[[4inc]], [[Resolution|resolution]] 1.19Å' scene=''> | + | <StructureSection load='4inc' size='340' side='right'caption='[[4inc]], [[Resolution|resolution]] 1.19Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4inc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4INC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4INC FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4inc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4INC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4INC FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ini|4ini]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4inc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4inc OCA], [https://pdbe.org/4inc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4inc RCSB], [https://www.ebi.ac.uk/pdbsum/4inc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4inc ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HINT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4inc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4inc OCA], [http://pdbe.org/4inc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4inc RCSB], [http://www.ebi.ac.uk/pdbsum/4inc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4inc ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/HINT2_HUMAN HINT2_HUMAN]] Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.<ref>PMID:16762638</ref> <ref>PMID:18653718</ref> | + | [https://www.uniprot.org/uniprot/HINT2_HUMAN HINT2_HUMAN] Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.<ref>PMID:16762638</ref> <ref>PMID:18653718</ref> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | ==See Also== | | ==See Also== |
| - | *[[Histidine triad nucleotide-binding protein|Histidine triad nucleotide-binding protein]] | + | *[[Histidine triad nucleotide-binding protein 3D structures|Histidine triad nucleotide-binding protein 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| - | [[Category: Finzel, B C]] | + | [[Category: Large Structures]] |
| - | [[Category: Maize, K M]] | + | [[Category: Finzel BC]] |
| - | [[Category: Wagner, C R]] | + | [[Category: Maize KM]] |
| - | [[Category: Hint]] | + | [[Category: Wagner CR]] |
| - | [[Category: Histidine triad]]
| + | |
| - | [[Category: Hit]]
| + | |
| - | [[Category: Hydrolase]]
| + | |
| - | [[Category: Phosphoramidase]]
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| Structural highlights
Function
HINT2_HUMAN Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.[1] [2]
Publication Abstract from PubMed
The histidine triad proteins (HITs) constitute a large and ubiquitous superfamily of nucleotide hydrolases. The human nucleotide binding proteins (hHints) are a distinct class of HITs noted for their acyl-AMP hydrolase and phosphoramidase activity. The first high resolution crystal structures of human Hint2 with and without bound adenosine monophosphate (AMP) are here described. The differences between hHint2 and previously known HIT-family protein structures are discussed. HIT-family enzymes have historically been divided into five classes based on their catalytic specificity: Hint, Fhit, GalT, DcpS, and Aprataxin. However, although several structures exist for enzymes in these classes, the endogenous substrates of many of these enzymes have not been identified or biochemically characterized. In order to better understand the structural relationship of the HIT enzymes, a structure-based phylogeny has been constructed that has resulted in the identification of several new putative HIT clades with potential acyl-AMP hydrolase and phosphoramidase activity. This article is protected by copyright. All rights reserved.
Structural characterization of human histidine triad nucleotide binding protein 2 (hHint2), a member of the histidine triad (HIT) superfamily.,Maize KM, Wagner CR, Finzel BC FEBS J. 2013 May 10. doi: 10.1111/febs.12330. PMID:23659632[3]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Martin J, Magnino F, Schmidt K, Piguet AC, Lee JS, Semela D, St-Pierre MV, Ziemiecki A, Cassio D, Brenner C, Thorgeirsson SS, Dufour JF. Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma. Gastroenterology. 2006 Jun;130(7):2179-88. PMID:16762638 doi:10.1053/j.gastro.2006.03.024
- ↑ Lenglet S, Antigny F, Vetterli L, Dufour JF, Rossier MF. Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis. Endocrinology. 2008 Nov;149(11):5461-9. doi: 10.1210/en.2008-0400. Epub 2008 Jul , 24. PMID:18653718 doi:10.1210/en.2008-0400
- ↑ Maize KM, Wagner CR, Finzel BC. Structural characterization of human histidine triad nucleotide binding protein 2 (hHint2), a member of the histidine triad (HIT) superfamily. FEBS J. 2013 May 10. doi: 10.1111/febs.12330. PMID:23659632 doi:10.1111/febs.12330
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