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4iua

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<StructureSection load='4iua' size='340' side='right'caption='[[4iua]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
<StructureSection load='4iua' size='340' side='right'caption='[[4iua]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4iua]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IUA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4iua]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IUA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nk1|1nk1]], [[2qj4|2qj4]], [[3hn4|3hn4]], [[3hmr|3hmr]], [[1gp9|1gp9]], [[1gmn|1gmn]], [[1gmo|1gmo]], [[1bht|1bht]], [[2hgf|2hgf]], [[2qj2|2qj2]], [[3hms|3hms]], [[3hmt|3hmt]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iua OCA], [https://pdbe.org/4iua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iua RCSB], [https://www.ebi.ac.uk/pdbsum/4iua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iua ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Hgf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iua OCA], [http://pdbe.org/4iua PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iua RCSB], [http://www.ebi.ac.uk/pdbsum/4iua PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iua ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HGF_MOUSE HGF_MOUSE]] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:20624990</ref>
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[https://www.uniprot.org/uniprot/HGF_MOUSE HGF_MOUSE] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:20624990</ref>
==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Kovach, A]]
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[[Category: Kovach A]]
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[[Category: Melcher, K]]
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[[Category: Melcher K]]
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[[Category: Tolbert, W D]]
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[[Category: Tolbert WD]]
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[[Category: Xu, H E]]
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[[Category: Xu HE]]
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[[Category: Zhou, E]]
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[[Category: Zhou E]]
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[[Category: Growth factor]]
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[[Category: Hgf/sf]]
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[[Category: Hormone]]
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[[Category: Kringle domain]]
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Revision as of 21:11, 16 November 2022

Crystal Structure of the NK2 Fragment (31-290) of the mouse Hepatocyte Growth Factor/Scatter Factor

PDB ID 4iua

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