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4iye

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<StructureSection load='4iye' size='340' side='right'caption='[[4iye]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4iye' size='340' side='right'caption='[[4iye]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4iye]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bmnh_1946.1.20.48 Bmnh 1946.1.20.48]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IYE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4iye]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IYE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vlw|2vlw]], [[3fev|3fev]], [[3neq|3neq]], [[4do8|4do8]], [[1ff4|1ff4]], [[2h5f|2h5f]], [[2h7z|2h7z]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iye OCA], [https://pdbe.org/4iye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iye RCSB], [https://www.ebi.ac.uk/pdbsum/4iye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iye ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iye OCA], [http://pdbe.org/4iye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iye RCSB], [http://www.ebi.ac.uk/pdbsum/4iye PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iye ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/3SI1A_DENAN 3SI1A_DENAN] Orthosteric antagonist of the alpha-1A adrenergic receptor (ADRA1A) with an affinity of 0.35 nM (PubMed:20015090). Has also affinity for ADRA1B > ADRA2C > ADRA1D (PubMed:23935897). Acts as a relaxant of smooth muscle. Reduces prostatic muscle tone as efficiently as tamsulosin (an antagonist presently used), but with fewer cardiovascular side effects (PubMed:23005263).<ref>PMID:20015090</ref> <ref>PMID:21419153</ref> <ref>PMID:23005263</ref> <ref>PMID:23935897</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bmnh 1946 1.20 48]]
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[[Category: Dendroaspis angusticeps]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bellanger, L]]
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[[Category: Bellanger L]]
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[[Category: Gilles, N]]
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[[Category: Gilles N]]
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[[Category: Lorphelin, A]]
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[[Category: Lorphelin A]]
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[[Category: Maiga, A A]]
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[[Category: Maiga AA]]
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[[Category: Marchetti, C]]
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[[Category: Marchetti C]]
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[[Category: Servant, D]]
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[[Category: Servant D]]
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[[Category: Stura, E A]]
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[[Category: Stura EA]]
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[[Category: Vera, L]]
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[[Category: Vera L]]
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[[Category: Acts as a relaxant of smooth muscle]]
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[[Category: Alpha-1a adrenergic receptor]]
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[[Category: Expressed by the venom gland]]
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[[Category: G-rhoda1a k34a]]
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[[Category: Snake three-finger toxin family]]
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[[Category: Toxin]]
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[[Category: Type a muscarinic toxin subfamily]]
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Revision as of 21:20, 16 November 2022

Crystal structure of AdTx1 (rho-Da1a) from eastern green mamba (Dendroaspis angusticeps)

PDB ID 4iye

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