4j0r

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==Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand==
==Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand==
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<StructureSection load='4j0r' size='340' side='right' caption='[[4j0r]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
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<StructureSection load='4j0r' size='340' side='right'caption='[[4j0r]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4j0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J0R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4j0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J0R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1H2:3-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-5-[(R)-HYDROXY(PHENYL)METHYL]PHENOL'>1H2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1H2:3-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-5-[(R)-HYDROXY(PHENYL)METHYL]PHENOL'>1H2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j0s|4j0s]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j0r OCA], [https://pdbe.org/4j0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j0r RCSB], [https://www.ebi.ac.uk/pdbsum/4j0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j0r ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j0r OCA], [http://pdbe.org/4j0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j0r RCSB], [http://www.ebi.ac.uk/pdbsum/4j0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j0r ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Bromodomain-containing protein|Bromodomain-containing protein]]
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Conway, S J]]
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[[Category: Bountra C]]
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[[Category: Delft, F von]]
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[[Category: Conway SJ]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Felletar, I]]
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[[Category: Felletar I]]
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[[Category: Filippakopoulos, P]]
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[[Category: Filippakopoulos P]]
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[[Category: Hewings, D S]]
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[[Category: Hewings DS]]
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[[Category: Knapp, S]]
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[[Category: Knapp S]]
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[[Category: Picaud, S]]
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[[Category: Picaud S]]
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[[Category: Qi, J]]
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[[Category: Qi J]]
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[[Category: Structural genomic]]
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[[Category: Von Delft F]]
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[[Category: Brd4]]
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[[Category: Bromodomain containing protein 4]]
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[[Category: Cap]]
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[[Category: Hunk1]]
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[[Category: Isoxazole]]
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[[Category: Mcap]]
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[[Category: Mitotic chromosome associated protein]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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Revision as of 21:22, 16 November 2022

Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand

PDB ID 4j0r

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