1hig

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(New page: 200px<br /> <applet load="1hig" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hig, resolution 3.5&Aring;" /> '''THREE-DIMENSIONAL ST...)
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Revision as of 15:12, 12 November 2007

Image:1hig.gif

1hig, resolution 3.5Å

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THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.

Contents

Overview

The x-ray crystal structure of recombinant human interferon-gamma has been, determined with the use of multiple-isomorphous-replacement techniques., Interferon-gamma, which is dimeric in solution, crystallizes with two, dimers related by a noncrystallographic twofold axis in the asymmetric, unit. The protein is primarily alpha helical, with six helices in each, subunit that comprise approximately 62 percent of the structure; there is, no beta sheet. The dimeric structure of human interferon-gamma is, stabilized by the intertwining of helices across the subunit interface, with multiple intersubunit interactions.

Disease

Known diseases associated with this structure: AIDS, rapid progression to OMIM:[147570], Aplastic anemia OMIM:[147570], Hepatitis C virus, resistance to OMIM:[147570], Interferon, immune, deficiency OMIM:[147570], TSC2 angiomyolipomas, renal, modifier of OMIM:[147570], Tuberculosis, susceptibility to OMIM:[147570]

About this Structure

1HIG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of recombinant human interferon-gamma., Ealick SE, Cook WJ, Vijay-Kumar S, Carson M, Nagabhushan TL, Trotta PP, Bugg CE, Science. 1991 May 3;252(5006):698-702. PMID:1902591

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