1hjo

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(New page: 200px<br /> <applet load="1hjo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hjo, resolution 2.30&Aring;" /> '''HEAT-SHOCK 70KD PRO...)
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Revision as of 15:12, 12 November 2007

Image:1hjo.gif

1hjo, resolution 2.30Å

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HEAT-SHOCK 70KD PROTEIN 42KD ATPASE N-TERMINAL DOMAIN

Overview

Hsp70 proteins are highly conserved proteins induced by heat shock and, other stress conditions. An ATP-binding domain of human Hsp70 protein has, been crystallized in two major morphological forms at pH 7.0 in the, presence of PEG 8000 and CaCl2. Both crystal forms belong to the, orthorhombic space group P212121, but show no resemblance in unit-cell, parameters. Analysis of the crystal structures for both forms shows a 1-2, A shift of one of the subdomains of the protein. This conformational, change could reflect a 'natural' flexibility of the protein which might be, relevant to ATP binding and may facilitate the interaction of other, proteins with Hsp70 protein.

About this Structure

1HJO is a Single protein structure of sequence from Homo sapiens with CA, CL and ADP as ligands. Active as Adenosinetriphosphatase, with EC number 3.6.1.3 Full crystallographic information is available from OCA.

Reference

Structure of a new crystal form of human Hsp70 ATPase domain., Osipiuk J, Walsh MA, Freeman BC, Morimoto RI, Joachimiak A, Acta Crystallogr D Biol Crystallogr. 1999 May;55(Pt 5):1105-7. PMID:10216320

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