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7sr4

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'''Unreleased structure'''
 
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The entry 7sr4 is ON HOLD until Paper Publication
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==Single chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 peptide YMLDLQPETTDLYC==
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<StructureSection load='7sr4' size='340' side='right'caption='[[7sr4]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7sr4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Pongo_pygmaeus Pongo pygmaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SR4 FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sr4 OCA], [https://pdbe.org/7sr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sr4 RCSB], [https://www.ebi.ac.uk/pdbsum/7sr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sr4 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VE7_HPV16 VE7_HPV16] Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).[HAMAP-Rule:MF_04004]<ref>PMID:11080488</ref> <ref>PMID:1316611</ref> <ref>PMID:2836062</ref> [https://www.uniprot.org/uniprot/A0A678ZGP6_HUMAN A0A678ZGP6_HUMAN] [https://www.uniprot.org/uniprot/B2MG_PONPY B2MG_PONPY] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Human papillomavirus type 16]]
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[[Category: Lama glama]]
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[[Category: Large Structures]]
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[[Category: Pongo pygmaeus]]
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[[Category: Finton KAK]]
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[[Category: Rupert PB]]

Revision as of 10:04, 24 November 2022

Single chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 peptide YMLDLQPETTDLYC

PDB ID 7sr4

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OCA

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