8amk

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'''Unreleased structure'''
 
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The entry 8amk is ON HOLD
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==Crystal structure of AUGUGGCAU duplex crystallized in the presence of calcium ions==
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<StructureSection load='8amk' size='340' side='right'caption='[[8amk]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8amk]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AMK FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8amk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8amk OCA], [https://pdbe.org/8amk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8amk RCSB], [https://www.ebi.ac.uk/pdbsum/8amk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8amk ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The self-complementary triplet 5'UGG3'/5'UGG3' is a particular structural motif containing noncanonical G-G pair and two U.G wobble pairs. It constitutes a specific structural and electrostatic environment attracting metal ions, particularly Ba2+ ions. Crystallographic research has shown that two Ba2+ cations are located in the major groove of the helix and interact directly with the UGG triplet. A comparison with the unliganded structure has revealed global changes in the RNA structure in the presence of metal ions, whereas thermodynamic measurements have shown increased stability. Moreover, in the structure with Ba2+, an unusual noncanonical G(syn)-G(syn) pair is observed instead of the common G(anti)-G(syn). We further elucidate the metal binding properties of the UGG/UGG triplet by performing crystallographic and thermodynamic studies using DSC and UV melting with other metal ions. The results explain the preferences of the UGG sequence for Ba2+ cations and point to possible applications of this metal-binding propensity.
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Authors: Kiliszek, A., Rypniewski, W.
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Structure and thermodynamics of a UGG motif interacting with Ba2+ and other metal ions: accommodating changes in the RNA structure and the presence of a G(syn)-G(syn) pair.,Kiliszek A, Pluta M, Bejger M, Rypniewski W RNA. 2022 Nov 1:rna.079414.122. doi: 10.1261/rna.079414.122. PMID:36319090<ref>PMID:36319090</ref>
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Description: Crystal structure of AUGUGGCAU duplex crystallized in the presence of calcium ions
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Rypniewski, W]]
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<div class="pdbe-citations 8amk" style="background-color:#fffaf0;"></div>
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[[Category: Kiliszek, A]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Kiliszek A]]
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[[Category: Rypniewski W]]

Revision as of 10:13, 24 November 2022

Crystal structure of AUGUGGCAU duplex crystallized in the presence of calcium ions

PDB ID 8amk

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