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1j3l

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[[Image:1j3l.gif|left|200px]]
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{{Structure
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j3l OCA], [http://www.ebi.ac.uk/pdbsum/1j3l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j3l RCSB]</span>
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'''Structure of the RNA-processing inhibitor RraA from Thermus thermophilis'''
'''Structure of the RNA-processing inhibitor RraA from Thermus thermophilis'''
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[[Category: Rehse, P H.]]
[[Category: Rehse, P H.]]
[[Category: Tahirov, T H.]]
[[Category: Tahirov, T H.]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: Rsgi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: vitamine k2]]
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[[Category: Vitamine k2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:45:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:28:23 2008''
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Revision as of 17:45, 2 May 2008

Image:1j3l.gif

Template:STRUCTURE 1j3l

Structure of the RNA-processing inhibitor RraA from Thermus thermophilis


Overview

The menG gene product, thought to catalyze the final methylation in vitamin K(2) synthesis, has recently been shown to inhibit RNase E in Eschericha coli. The structure of the protein, since renamed RraA, has been solved to 2.3 A using the multiple-wavelength anomalous diffraction method and selenomethionine-substituted protein from Thermus thermophilus. The six molecules in the asymmetric unit are arranged as two similar trimers which have a degree of interaction, suggesting biological significance. The fold does not support the postulated methylation function. Genomic analysis, specifically a lack of an RNase E homologue in cases where homologues to RraA exist, indicates that the function is still obscure.

About this Structure

1J3L is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Structure of the RNA-processing inhibitor RraA from Thermus thermophilis., Rehse PH, Kuroishi C, Tahirov TH, Acta Crystallogr D Biol Crystallogr. 2004 Nov;60(Pt 11):1997-2002. Epub, 2004 Oct 20. PMID:15502308 Page seeded by OCA on Fri May 2 20:45:54 2008

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