8bfm

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m (Protected "8bfm" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8bfm is ON HOLD
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==Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) in complex with FZ331==
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<StructureSection load='8bfm' size='340' side='right'caption='[[8bfm]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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Authors: Kraemer, A., Zhu, W.F., Hernandez-Olmos, V., Proschak, E., Knapp, S., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8bfm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BFM FirstGlance]. <br>
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Description: Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) in complex with FZ331
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QI6:pyrazolo[5,1-a]phthalazin-6-amine'>QI6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bfm OCA], [https://pdbe.org/8bfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bfm RCSB], [https://www.ebi.ac.uk/pdbsum/8bfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bfm ProSAT]</span></td></tr>
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[[Category: Proschak, E]]
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</table>
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[[Category: Knapp, S]]
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== Function ==
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[[Category: Hernandez-Olmos, V]]
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[https://www.uniprot.org/uniprot/KCC1D_HUMAN KCC1D_HUMAN] Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.<ref>PMID:11050006</ref> <ref>PMID:15840691</ref> <ref>PMID:16324104</ref> <ref>PMID:17056143</ref>
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[[Category: Structural Genomics Consortium (Sgc)]]
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== References ==
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[[Category: Zhu, W.F]]
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<references/>
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[[Category: Kraemer, A]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hernandez-Olmos V]]
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[[Category: Knapp S]]
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[[Category: Kraemer A]]
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[[Category: Proschak E]]
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[[Category: Zhu WF]]

Revision as of 10:14, 24 November 2022

Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) in complex with FZ331

PDB ID 8bfm

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OCA

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