7ul3

<StructureSection load='7ul3' size='340' side='right'caption='[[7ul3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[7ul3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UL3 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FO9:famotidine'>FO9</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ul3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ul3 OCA], [https://pdbe.org/7ul3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ul3 RCSB], [https://www.ebi.ac.uk/pdbsum/7ul3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ul3 ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/HRH2_HUMAN HRH2_HUMAN] The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).[https://www.uniprot.org/uniprot/A0A8B8VNB6_BALMU A0A8B8VNB6_BALMU] G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.[ARBA:ARBA00025353]

[[Category: Homo sapiens]]

[[Category: Robertson MJ]]

[[Category: Skiniotis G]]