4jb9

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<StructureSection load='4jb9' size='340' side='right'caption='[[4jb9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4jb9' size='340' side='right'caption='[[4jb9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jb9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JB9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JB9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jb9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JB9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j6r|4j6r]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jb9 OCA], [https://pdbe.org/4jb9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jb9 RCSB], [https://www.ebi.ac.uk/pdbsum/4jb9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jb9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jb9 OCA], [http://pdbe.org/4jb9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jb9 RCSB], [http://www.ebi.ac.uk/pdbsum/4jb9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jb9 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q0ED31_9HIV1 Q0ED31_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Gp120|Gp120]]
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*[[Gp120 3D structures|Gp120 3D structures]]
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*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Human immunodeficiency virus 1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kwon, Y D]]
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[[Category: Kwon YD]]
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[[Category: Kwong, P D]]
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[[Category: Kwong PD]]
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[[Category: Srivatsan, S]]
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[[Category: Srivatsan S]]
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[[Category: Zhou, T]]
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[[Category: Zhou T]]
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[[Category: Antibody]]
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[[Category: Glycoprotein]]
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[[Category: Gp120]]
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[[Category: Hiv-1]]
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[[Category: Immune system]]
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[[Category: Viral protein-immune system complex]]
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[[Category: Vrc06]]
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Revision as of 11:03, 24 November 2022

Crystal structure of antibody VRC06 in complex with HIV-1 gp120 core

PDB ID 4jb9

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