4jbk

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==Molecular basis for abrogation of activation of pro-inflammatory cytokines==
==Molecular basis for abrogation of activation of pro-inflammatory cytokines==
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<StructureSection load='4jbk' size='340' side='right' caption='[[4jbk]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
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<StructureSection load='4jbk' size='340' side='right'caption='[[4jbk]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jbk]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JBK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jbk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBK FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jbj|4jbj]], [[4jbm|4jbm]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbk OCA], [https://pdbe.org/4jbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jbk RCSB], [https://www.ebi.ac.uk/pdbsum/4jbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbk ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ifi202a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbk OCA], [http://pdbe.org/4jbk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jbk RCSB], [http://www.ebi.ac.uk/pdbsum/4jbk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbk ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE]] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref>
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[https://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Cheng, G]]
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[[Category: Mus musculus]]
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[[Category: Crowley, C]]
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[[Category: Cheng G]]
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[[Category: Ding, W]]
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[[Category: Crowley C]]
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[[Category: Hung, L W]]
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[[Category: Ding W]]
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[[Category: Liu, Z J]]
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[[Category: Hung L-W]]
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[[Category: Ni, X]]
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[[Category: Liu Z-J]]
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[[Category: Ru, H]]
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[[Category: Ni X]]
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[[Category: Shaw, N]]
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[[Category: Ru H]]
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[[Category: Zhao, L]]
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[[Category: Shaw N]]
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[[Category: Dna]]
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[[Category: Zhao L]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Ob fold]]
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Revision as of 11:03, 24 November 2022

Molecular basis for abrogation of activation of pro-inflammatory cytokines

PDB ID 4jbk

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