1hla

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(New page: 200px<br /> <applet load="1hla" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hla, resolution 3.5&Aring;" /> '''STRUCTURE OF THE HUM...)
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Revision as of 15:13, 12 November 2007

Image:1hla.gif

1hla, resolution 3.5Å

Drag the structure with the mouse to rotate

STRUCTURE OF THE HUMAN CLASS I HISTOCOMPATIBILITY ANTIGEN, HLA-A2

Contents

Overview

The class I histocompatibility antigen from human cell membranes has two, structural motifs: the membrane-proximal end of the glycoprotein contains, two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the membrane is a platform of eight, antiparallel beta-strands topped by alpha-helices. A large groove between, the alpha-helices provides a binding site for processed foreign antigens., An unknown 'antigen' is found in this site in crystals of purified HLA-A2.

Disease

Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]

About this Structure

1HLA is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the human class I histocompatibility antigen, HLA-A2., Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC, Nature. 1987 Oct 8-14;329(6139):506-12. PMID:3309677

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