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4jgw

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Revision as of 11:12, 24 November 2022

The conformation of a docking site for SH3 domains is pre-selected in the Guanine Nucleotide Exchange Factor Rlf

Structural highlights

4jgw is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RGL2_MOUSE Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro.

Publication Abstract from PubMed

Rlf is a guanine nucleotide exchange factor for the small G-proteins RalA and RalB and couples Ras- to Ral-signalling. Here the crystal structure of the catalytic module of Rlf consisting of a REM- and a CDC25-homology domain is determined. The structure is distinguished by an extended three stranded beta-sheet called the flagpole. The flagpole is a conserved element in the RalGDS family of guanine nucleotide exchange factors and stabilises the orientation of the REM-domain relative to the CDC25-homology domain. A proline-rich sequence in the flagpole is unique to Rlf and several proteins that interact with this sequence by SH3 domains are identified. Conformational pre-selection results in a gain of affinity and contributes to the establishment of SH3 domain selectivity.

The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation.,Popovic M, Jakobi AJ, Rensen-de Leeuw M, Rehmann H J Struct Biol. 2013 Sep;183(3):312-9. doi: 10.1016/j.jsb.2013.07.009. Epub 2013, Jul 24. PMID:23891840^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Popovic M, Jakobi AJ, Rensen-de Leeuw M, Rehmann H. The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation. J Struct Biol. 2013 Sep;183(3):312-9. doi: 10.1016/j.jsb.2013.07.009. Epub 2013, Jul 24. PMID:23891840 doi:10.1016/j.jsb.2013.07.009

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4jgw"

Categories: Large Structures | Mus musculus | Jakobi AJ | Popovic M | Rehmann H

@@ Line 1: / Line 1: @@
 ==The conformation of a docking site for SH3 domains is pre-selected in the Guanine Nucleotide Exchange Factor Rlf==
-<StructureSection load='4jgw' size='340' side='right' caption='[[4jgw]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+<StructureSection load='4jgw' size='340' side='right'caption='[[4jgw]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4jgw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JGW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4jgw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JGW FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rgl2, Rab2l, Rlf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgw OCA], [https://pdbe.org/4jgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jgw RCSB], [https://www.ebi.ac.uk/pdbsum/4jgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgw ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgw OCA], [http://pdbe.org/4jgw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jgw RCSB], [http://www.ebi.ac.uk/pdbsum/4jgw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgw ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/RGL2_MOUSE RGL2_MOUSE]] Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro.
+[https://www.uniprot.org/uniprot/RGL2_MOUSE RGL2_MOUSE] Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 22: / Line 21: @@
 __TOC__
 </StructureSection>
-[[Category: Lk3 transgenic mice]]
+[[Category: Large Structures]]
-[[Category: Jakobi, A J]]
+[[Category: Mus musculus]]
-[[Category: Popovic, M]]
+[[Category: Jakobi AJ]]
-[[Category: Rehmann, H]]
+[[Category: Popovic M]]
-[[Category: Cdc25-homology domain]]
+[[Category: Rehmann H]]
-[[Category: Guanine nucleotide exchange factor]]
-[[Category: Rem-domain]]
-[[Category: Sh3 domain binding]]
-[[Category: Signaling protein]]
-[[Category: Small g-protein binding]]

4jgw

From Proteopedia

Revision as of 11:12, 24 November 2022

The conformation of a docking site for SH3 domains is pre-selected in the Guanine Nucleotide Exchange Factor Rlf

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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