4jgz

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<StructureSection load='4jgz' size='340' side='right'caption='[[4jgz]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4jgz' size='340' side='right'caption='[[4jgz]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jgz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_coxsackievirus_a16 Human coxsackievirus a16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JGZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jgz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A16 Coxsackievirus A16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JGZ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgz OCA], [http://pdbe.org/4jgz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jgz RCSB], [http://www.ebi.ac.uk/pdbsum/4jgz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgz ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgz OCA], [https://pdbe.org/4jgz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jgz RCSB], [https://www.ebi.ac.uk/pdbsum/4jgz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/I3W9E1_9ENTO I3W9E1_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
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[https://www.uniprot.org/uniprot/I3W9E1_9ENTO I3W9E1_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4jgz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4jgz" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human coxsackievirus a16]]
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[[Category: Coxsackievirus A16]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Axford, D]]
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[[Category: Axford D]]
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[[Category: Fry, E E]]
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[[Category: Fry EE]]
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[[Category: Gao, Q]]
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[[Category: Gao Q]]
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[[Category: Gilbert, R J]]
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[[Category: Gilbert RJ]]
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[[Category: Hu, Z]]
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[[Category: Hu Z]]
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[[Category: Li, X]]
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[[Category: Li X]]
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[[Category: McAuley, K]]
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[[Category: McAuley K]]
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[[Category: Porta, C]]
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[[Category: Porta C]]
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[[Category: Rao, Z]]
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[[Category: Rao Z]]
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[[Category: Ren, J]]
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[[Category: Ren J]]
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[[Category: Rowlands, D J]]
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[[Category: Rowlands DJ]]
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[[Category: Stuart, D I]]
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[[Category: Stuart DI]]
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[[Category: Sun, Y]]
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[[Category: Sun Y]]
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[[Category: Walter, T S]]
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[[Category: Walter TS]]
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[[Category: Wang, J]]
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[[Category: Wang J]]
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[[Category: Wang, X]]
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[[Category: Wang X]]
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[[Category: Williams, M]]
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[[Category: Williams M]]
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[[Category: Yin, W]]
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[[Category: Yin W]]
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[[Category: Zhao, Y]]
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[[Category: Zhao Y]]
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[[Category: Hand-foot-and-mouth disease]]
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[[Category: Icosahedral virus]]
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[[Category: Picornavirus uncoating]]
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[[Category: Pocket factor]]
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[[Category: Virus]]
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Revision as of 11:12, 24 November 2022

Crystal structure of human coxsackievirus A16 uncoating intermediate (space group I222)

PDB ID 4jgz

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