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4jhr

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==An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs==
==An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs==
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<StructureSection load='4jhr' size='340' side='right' caption='[[4jhr]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='4jhr' size='340' side='right'caption='[[4jhr]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jhr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JHR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jhr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JHR FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gpsm2, Lgn, Pins ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jhr OCA], [https://pdbe.org/4jhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jhr RCSB], [https://www.ebi.ac.uk/pdbsum/4jhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jhr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jhr OCA], [http://pdbe.org/4jhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jhr RCSB], [http://www.ebi.ac.uk/pdbsum/4jhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jhr ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GPSM2_MOUSE GPSM2_MOUSE]] Plays an important role in spindle pole orientation (By similarity). Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.
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[https://www.uniprot.org/uniprot/GPSM2_MOUSE GPSM2_MOUSE] Plays an important role in spindle pole orientation (By similarity). Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Jia, M]]
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[[Category: Mus musculus]]
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[[Category: Pan, Z]]
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[[Category: Jia M]]
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[[Category: Shang, Y]]
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[[Category: Pan Z]]
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[[Category: Wang, W]]
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[[Category: Shang Y]]
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[[Category: Wei, Z]]
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[[Category: Wang W]]
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[[Category: Wen, W]]
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[[Category: Wei Z]]
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[[Category: Xia, C]]
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[[Category: Wen W]]
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[[Category: Zhang, M]]
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[[Category: Xia C]]
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[[Category: Zhu, J]]
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[[Category: Zhang M]]
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[[Category: Asymmetric cell division]]
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[[Category: Zhu J]]
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[[Category: Goloco]]
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[[Category: Goloco tandem motif]]
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[[Category: Lgn]]
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[[Category: Signaling protein]]
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[[Category: Tpr motif]]
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Revision as of 11:14, 24 November 2022

An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs

PDB ID 4jhr

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