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4jls

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<StructureSection load='4jls' size='340' side='right'caption='[[4jls]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4jls' size='340' side='right'caption='[[4jls]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jls]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_mds42 Escherichia coli mds42]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JLS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jls]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._MDS42 Escherichia coli str. K-12 substr. MDS42]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JLS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3ZE:{2-[(3S,4R)-3-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-4-HYDROXYPYRROLIDIN-1-YL]-2-OXOETHYL}PHOSPHONIC+ACID'>3ZE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3ZE:{2-[(3S,4R)-3-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-4-HYDROXYPYRROLIDIN-1-YL]-2-OXOETHYL}PHOSPHONIC+ACID'>3ZE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jit|4jit]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jls OCA], [https://pdbe.org/4jls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jls RCSB], [https://www.ebi.ac.uk/pdbsum/4jls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jls ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gpt, ECMDS42_0227 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1110693 Escherichia coli MDS42])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xanthine_phosphoribosyltransferase Xanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.22 2.4.2.22] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jls OCA], [http://pdbe.org/4jls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jls RCSB], [http://www.ebi.ac.uk/pdbsum/4jls PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jls ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/H0Q6L9_ECOLI H0Q6L9_ECOLI]] Acts on guanine, xanthine and to a lesser extent hypoxanthine.[HAMAP-Rule:MF_01903][SAAS:SAAS00010659]
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[https://www.uniprot.org/uniprot/XGPT_ECOLI XGPT_ECOLI] Acts on guanine, xanthine and to a lesser extent hypoxanthine.<ref>PMID:9100006</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Phosphoribosyltransferase|Phosphoribosyltransferase]]
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli mds42]]
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[[Category: Escherichia coli str. K-12 substr. MDS42]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Xanthine phosphoribosyltransferase]]
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[[Category: Eng WS]]
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[[Category: Eng, W S]]
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[[Category: Guddat LW]]
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[[Category: Guddat, L W]]
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[[Category: Hockova D]]
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[[Category: Hockova, D]]
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[[Category: Jans H]]
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[[Category: Jans, H]]
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[[Category: Keough DT]]
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[[Category: Jersey, J de]]
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[[Category: Krecmerova M]]
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[[Category: Keough, D T]]
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[[Category: Naesens LMJ]]
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[[Category: Krecmerova, M]]
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[[Category: Rejman D]]
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[[Category: Naesens, L M.J]]
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[[Category: Spacek P]]
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[[Category: Rejman, D]]
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[[Category: Vrbkova S]]
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[[Category: Spacek, P]]
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[[Category: West NP]]
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[[Category: Vrbkova, S]]
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[[Category: De Jersey J]]
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[[Category: West, N P]]
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[[Category: Antibacterial]]
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[[Category: Nucleoside phosphonate]]
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[[Category: Purine salvage]]
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[[Category: Transferase]]
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[[Category: Xanthine-guanine phosphoribosyltransferase]]
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Revision as of 11:21, 24 November 2022

Crystal Structure of E. coli XGPRT in complex with (3R,4S)-4-(Guanin-9-yl)-3-hydroxypyrrolidin-1-N-ylacetylphosphonic acid

PDB ID 4jls

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