1j53

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[[Image:1j53.gif|left|200px]]
[[Image:1j53.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1j53 |SIZE=350|CAPTION= <scene name='initialview01'>1j53</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1j53", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TMP:THYMIDINE-5&#39;-PHOSPHATE'>TMP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1j53| PDB=1j53 | SCENE= }}
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|RELATEDENTRY=[[1j54|1J54]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j53 OCA], [http://www.ebi.ac.uk/pdbsum/1j53 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j53 RCSB]</span>
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}}
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'''Structure of the N-terminal Exonuclease Domain of the Epsilon Subunit of E.coli DNA Polymerase III at pH 8.5'''
'''Structure of the N-terminal Exonuclease Domain of the Epsilon Subunit of E.coli DNA Polymerase III at pH 8.5'''
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[[Category: Hamdan, S.]]
[[Category: Hamdan, S.]]
[[Category: Ollis, D L.]]
[[Category: Ollis, D L.]]
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[[Category: dna polymerase proofreading domain]]
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[[Category: Dna polymerase proofreading domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:48:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:28:55 2008''
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Revision as of 17:48, 2 May 2008

Image:1j53.gif

Template:STRUCTURE 1j53

Structure of the N-terminal Exonuclease Domain of the Epsilon Subunit of E.coli DNA Polymerase III at pH 8.5


Overview

The epsilon subunit of the Escherichia coli replicative DNA polymerase III is the proofreading 3'-5' exonuclease. Structures of its catalytic N-terminal domain (epsilon186) were determined at two pH values (5.8 and 8.5) at resolutions of 1.7-1.8 A, in complex with two Mn(II) ions and a nucleotide product of its reaction, thymidine 5'-monophosphate. The protein structure is built around a core five-stranded beta sheet that is a common feature of members of the DnaQ superfamily. The structures were identical, except for differences in the way TMP and water molecules are coordinated to the binuclear metal center in the active site. These data are used to develop a mechanism for epsilon and to produce a plausible model of the complex of epsilon186 with DNA.

About this Structure

1J53 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis for proofreading during replication of the Escherichia coli chromosome., Hamdan S, Carr PD, Brown SE, Ollis DL, Dixon NE, Structure. 2002 Apr;10(4):535-46. PMID:11937058 Page seeded by OCA on Fri May 2 20:48:53 2008

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