4jqh

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==Crystal structure of a new sGC activator (analogue of BAY 58-2667) bound to nostoc H-NOX domain==
==Crystal structure of a new sGC activator (analogue of BAY 58-2667) bound to nostoc H-NOX domain==
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<StructureSection load='4jqh' size='340' side='right' caption='[[4jqh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4jqh' size='340' side='right'caption='[[4jqh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jqh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anabaena_7120 Anabaena 7120]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JQH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jqh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_sp._PCC_7120_=_FACHB-418 Nostoc sp. PCC 7120 = FACHB-418]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JQH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MF:4-{[(4-CARBOXYBUTYL)(2-{2-[(4-PHENOXYBIPHENYL-4-YL)METHOXY]PHENYL}ETHYL)AMINO]METHYL}BENZOIC+ACID'>1MF</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MF:4-{[(4-CARBOXYBUTYL)(2-{2-[(4-PHENOXYBIPHENYL-4-YL)METHOXY]PHENYL}ETHYL)AMINO]METHYL}BENZOIC+ACID'>1MF</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3l6j|3l6j]], [[4iae|4iae]], [[4iah|4iah]], [[4iam|4iam]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jqh OCA], [https://pdbe.org/4jqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jqh RCSB], [https://www.ebi.ac.uk/pdbsum/4jqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jqh ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">alr2278 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=103690 Anabaena 7120])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_cyclase Guanylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.2 4.6.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jqh OCA], [http://pdbe.org/4jqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jqh RCSB], [http://www.ebi.ac.uk/pdbsum/4jqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jqh ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8YUQ7_NOSS1 Q8YUQ7_NOSS1]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Anabaena 7120]]
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[[Category: Large Structures]]
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[[Category: Guanylate cyclase]]
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[[Category: Nostoc sp. PCC 7120 = FACHB-418]]
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[[Category: Akker, F van den]]
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[[Category: Kumar V]]
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[[Category: Kumar, V]]
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[[Category: Van den Akker F]]
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[[Category: Analogue of bay58-2667]]
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[[Category: Guanylyl cyclase]]
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[[Category: Signaling protein]]
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Revision as of 11:30, 24 November 2022

Crystal structure of a new sGC activator (analogue of BAY 58-2667) bound to nostoc H-NOX domain

PDB ID 4jqh

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