The glyoxylate cycle, a variation of the tricarboxylic acid cycle, is an anabolic pathway occurring in plants, bacteria, protists, and fungi. The glyoxylate cycle centers on the conversion of acetyl-CoA to succinate for the synthesis of carbohydrates.
The glyoxylate cycle uses six of the eight enzymes associated with the tricarboxylic acid cycle: citrate synthase, aconitase, succinate dehydrogenase, fumarase, and malate dehydrogenase.
Citrate Synthase
4C to a 6C molecule
Aconitase
6C Citrate => 6C
6C cis-Aconitate => 6C
Succinate Dehydrogenase
=>
Fumarase
Fumarate =>
Malate dehydrogenase
L-Malate =>
The two cycles differ in that in the glyoxylate cycle, is converted into and by isocitrate lyase (ICL) instead of into α-ketoglutarate.
. The ternary complex contains malate, acetyl-CoA and Mg+2 ion[1].
