1j6s
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1j6s.gif|left|200px]] | [[Image:1j6s.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1j6s", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1j6s| PDB=1j6s | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''Crystal Structure of an RNA Tetraplex (UGAGGU)4 with A-tetrads, G-tetrads, U-tetrads and G-U octads''' | '''Crystal Structure of an RNA Tetraplex (UGAGGU)4 with A-tetrads, G-tetrads, U-tetrads and G-U octads''' | ||
| Line 19: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J6S OCA]. | |
==Reference== | ==Reference== | ||
Crystal structure of an RNA purine-rich tetraplex containing adenine tetrads: implications for specific binding in RNA tetraplexes., Pan B, Xiong Y, Shi K, Deng J, Sundaralingam M, Structure. 2003 Jul;11(7):815-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12842044 12842044] | Crystal structure of an RNA purine-rich tetraplex containing adenine tetrads: implications for specific binding in RNA tetraplexes., Pan B, Xiong Y, Shi K, Deng J, Sundaralingam M, Structure. 2003 Jul;11(7):815-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12842044 12842044] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Deng, J.]] | [[Category: Deng, J.]] | ||
[[Category: Pan, B.]] | [[Category: Pan, B.]] | ||
| Line 29: | Line 25: | ||
[[Category: Sundaralingam, M.]] | [[Category: Sundaralingam, M.]] | ||
[[Category: Xiong, Y.]] | [[Category: Xiong, Y.]] | ||
| - | [[Category: | + | [[Category: A-tetrad]] |
| - | [[Category: | + | [[Category: G-tetrad]] |
| - | [[Category: | + | [[Category: G-u octad]] |
| - | [[Category: | + | [[Category: Rna]] |
| - | [[Category: | + | [[Category: Tetraplex]] |
| - | [[Category: | + | [[Category: U-tetrad]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:51:12 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:51, 2 May 2008
Crystal Structure of an RNA Tetraplex (UGAGGU)4 with A-tetrads, G-tetrads, U-tetrads and G-U octads
Overview
Purine-rich regions in DNA and RNA may contain both guanines and adenines, which have various biological functions. Here we report the crystal structure of an RNA purine-rich fragment containing both guanine and adenine at 1.4 A resolution. Adenines form an adenine tetrad in the N6-H em leader N7 conformation. Substitution of an adenine tetrad in the guanine tetraplex does not change the global conformation but introduces irregularity in both the hydrogen bonding interaction pattern in the groove and the metal ion binding pattern in the central cavity of the tetraplex. The irregularity in groove binding may be critical for specific binding in tetraplexes. The formation of G-U octads provides a mechanism for interaction in the groove. Ba(2+) ions prefer to bind guanine tetrads, and adenine tetrads can only be bound by Na(+) ions, illustrating the binding selectivity of metal ions for the tetraplex.
About this Structure
Full crystallographic information is available from OCA.
Reference
Crystal structure of an RNA purine-rich tetraplex containing adenine tetrads: implications for specific binding in RNA tetraplexes., Pan B, Xiong Y, Shi K, Deng J, Sundaralingam M, Structure. 2003 Jul;11(7):815-23. PMID:12842044 Page seeded by OCA on Fri May 2 20:51:12 2008
