8blu

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m (Protected "8blu" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8blu is ON HOLD
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==The PDZ domains of human SDCBP==
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<StructureSection load='8blu' size='340' side='right'caption='[[8blu]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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Authors: Bradshaw, W.J., Katis, V.L., Daniel-Mozo, M., Bountra, C., von Delft, F., Brennan, P.E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8blu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BLU FirstGlance]. <br>
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Description: The PDZ domains of human SDCBP
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8blu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8blu OCA], [https://pdbe.org/8blu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8blu RCSB], [https://www.ebi.ac.uk/pdbsum/8blu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8blu ProSAT]</span></td></tr>
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[[Category: Katis, V.L]]
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</table>
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[[Category: Daniel-Mozo, M]]
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== Function ==
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[[Category: Brennan, P.E]]
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[https://www.uniprot.org/uniprot/SDCB1_HUMAN SDCB1_HUMAN] Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.<ref>PMID:10230395</ref> <ref>PMID:11179419</ref> <ref>PMID:11498591</ref>
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[[Category: Bradshaw, W.J]]
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== References ==
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[[Category: Von Delft, F]]
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<references/>
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[[Category: Bountra, C]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bountra C]]
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[[Category: Bradshaw WJ]]
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[[Category: Brennan PE]]
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[[Category: Daniel-Mozo M]]
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[[Category: Katis VL]]
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[[Category: Von Delft F]]

Revision as of 10:45, 30 November 2022

The PDZ domains of human SDCBP

PDB ID 8blu

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