8e9w
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==CryoEM structure of miniGq-coupled hM3Dq in complex with DCZ== | |
| - | + | <StructureSection load='8e9w' size='340' side='right'caption='[[8e9w]], [[Resolution|resolution]] 2.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8e9w]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E9W FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WEC:11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine'>WEC</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e9w OCA], [https://pdbe.org/8e9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e9w RCSB], [https://www.ebi.ac.uk/pdbsum/8e9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e9w ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[https://omim.org/entry/100100 100100]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Fay JF]] | ||
| + | [[Category: Roth BL]] | ||
| + | [[Category: Zhang S]] | ||
Revision as of 10:46, 30 November 2022
CryoEM structure of miniGq-coupled hM3Dq in complex with DCZ
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