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8e9z

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'''Unreleased structure'''
 
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The entry 8e9z is ON HOLD until Paper Publication
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==CryoEM structure of miniGq-coupled hM3R in complex with Iperoxo==
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<StructureSection load='8e9z' size='340' side='right'caption='[[8e9z]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8e9z]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E9Z FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e9z OCA], [https://pdbe.org/8e9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e9z RCSB], [https://www.ebi.ac.uk/pdbsum/8e9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e9z ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[https://omim.org/entry/100100 100100]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Fay JF]]
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[[Category: Roth BL]]
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[[Category: Zhang S]]

Revision as of 10:47, 30 November 2022

CryoEM structure of miniGq-coupled hM3R in complex with Iperoxo

PDB ID 8e9z

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