1j6z

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[[Image:1j6z.gif|left|200px]]
[[Image:1j6z.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1j6z |SIZE=350|CAPTION= <scene name='initialview01'>1j6z</scene>, resolution 1.54&Aring;
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The line below this paragraph, containing "STRUCTURE_1j6z", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>, <scene name='pdbligand=RHO:TETRAMETHYLRHODAMINE-5-MALEIMIDE'>RHO</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1j6z| PDB=1j6z | SCENE= }}
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|RELATEDENTRY=[[1atn|1ATN]], [[2btf|2BTF]], [[1db0|1DB0]], [[1dga|1DGA]], [[1eqy|1EQY]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j6z OCA], [http://www.ebi.ac.uk/pdbsum/1j6z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j6z RCSB]</span>
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}}
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'''UNCOMPLEXED ACTIN'''
'''UNCOMPLEXED ACTIN'''
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[[Category: Graceffa, P.]]
[[Category: Graceffa, P.]]
[[Category: Otterbein, L R.]]
[[Category: Otterbein, L R.]]
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[[Category: actin]]
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[[Category: Actin]]
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[[Category: adp-state]]
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[[Category: Adp-state]]
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[[Category: tetramethylrhodamine-5-maleimide]]
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[[Category: Tetramethylrhodamine-5-maleimide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:51:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:29:24 2008''
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Revision as of 17:51, 2 May 2008

Image:1j6z.gif

Template:STRUCTURE 1j6z

UNCOMPLEXED ACTIN


Overview

The dynamics and polarity of actin filaments are controlled by a conformational change coupled to the hydrolysis of adenosine 5'-triphosphate (ATP) by a mechanism that remains to be elucidated. Actin modified to block polymerization was crystallized in the adenosine 5'-diphosphate (ADP) state, and the structure was solved to 1.54 angstrom resolution. Compared with previous ATP-actin structures from complexes with deoxyribonuclease I, profilin, and gelsolin, monomeric ADP-actin is characterized by a marked conformational change in subdomain 2. The successful crystallization of monomeric actin opens the way to future structure determinations of actin complexes with actin-binding proteins such as myosin.

About this Structure

1J6Z is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of uncomplexed actin in the ADP state., Otterbein LR, Graceffa P, Dominguez R, Science. 2001 Jul 27;293(5530):708-11. PMID:11474115 Page seeded by OCA on Fri May 2 20:51:32 2008

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OCA

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