1j75
From Proteopedia
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'''Crystal Structure of the DNA-Binding Domain Zalpha of DLM-1 Bound to Z-DNA''' | '''Crystal Structure of the DNA-Binding Domain Zalpha of DLM-1 Bound to Z-DNA''' | ||
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[[Category: Rich, A.]] | [[Category: Rich, A.]] | ||
[[Category: Schwartz, T.]] | [[Category: Schwartz, T.]] | ||
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Revision as of 17:52, 2 May 2008
Crystal Structure of the DNA-Binding Domain Zalpha of DLM-1 Bound to Z-DNA
Overview
The first crystal structure of a protein, the Z alpha high affinity binding domain of the RNA editing enzyme ADAR1, bound to left-handed Z-DNA was recently described. The essential set of residues determined from this structure to be critical for Z-DNA recognition was used to search the database for other proteins with the potential for Z-DNA binding. We found that the tumor-associated protein DLM-1 contains a domain with remarkable sequence similarities to Z alpha(ADAR). Here we report the crystal structure of this DLM-1 domain bound to left-handed Z-DNA at 1.85 A resolution. Comparison of Z-DNA binding by DLM-1 and ADAR1 reveals a common structure-specific recognition core within the binding domain. However, the domains differ in certain residues peripheral to the protein-DNA interface. These structures reveal a general mechanism of Z-DNA recognition, suggesting the existence of a family of winged-helix proteins sharing a common Z-DNA binding motif.
About this Structure
1J75 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins., Schwartz T, Behlke J, Lowenhaupt K, Heinemann U, Rich A, Nat Struct Biol. 2001 Sep;8(9):761-5. PMID:11524677 Page seeded by OCA on Fri May 2 20:51:59 2008
