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| | ==Dimeric structure of CARMA1 CARD== | | ==Dimeric structure of CARMA1 CARD== |
| - | <StructureSection load='4jup' size='340' side='right' caption='[[4jup]], [[Resolution|resolution]] 3.20Å' scene=''> | + | <StructureSection load='4jup' size='340' side='right'caption='[[4jup]], [[Resolution|resolution]] 3.20Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4jup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JUP FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4jup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JUP FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CARD11, CARMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jup OCA], [https://pdbe.org/4jup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jup RCSB], [https://www.ebi.ac.uk/pdbsum/4jup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jup ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jup OCA], [http://pdbe.org/4jup PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jup RCSB], [http://www.ebi.ac.uk/pdbsum/4jup PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jup ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Disease == | | == Disease == |
| - | [[http://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | + | [https://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN] Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. | + | [https://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| - | [[Category: Park, H H]] | + | [[Category: Large Structures]] |
| - | [[Category: Protein binding]] | + | [[Category: Park HH]] |
| - | [[Category: Protein interaction]]
| + | |
| Structural highlights
Disease
CAR11_HUMAN Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
Function
CAR11_HUMAN Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
Publication Abstract from PubMed
CARMA1, BCL10 and MALT1 form a large molecular complex known as the CARMA1 signalosome during lymphocyte activation. Lymphocyte activation via the CARMA1 signalosome is critical to immune response and linked to many immune diseases. Despite the important role of the CARMA1 signalosome during lymphocyte activation and proliferation, limited structural information is available. Here, we report the dimeric structure of CARMA1 CARD at a resolution of 3.2 A. Interestingly, although CARMA1 CARD has a canonical six helical-bundles structural fold similar to other CARDs, CARMA1 CARD shows the first homo-dimeric structure of CARD formed by a disulfide bond and reveals a possible biologically important homo-dimerization mechanism.
Novel disulfide bond-mediated dimerization of the CARD domain was revealed by the crystal structure of CARMA1 CARD.,Jang TH, Park JH, Park HH PLoS One. 2013 Nov 5;8(11):e79778. doi: 10.1371/journal.pone.0079778. eCollection, 2013. PMID:24224005[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Jang TH, Park JH, Park HH. Novel disulfide bond-mediated dimerization of the CARD domain was revealed by the crystal structure of CARMA1 CARD. PLoS One. 2013 Nov 5;8(11):e79778. doi: 10.1371/journal.pone.0079778. eCollection, 2013. PMID:24224005 doi:http://dx.doi.org/10.1371/journal.pone.0079778
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