4jwe

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==Crystal structure of the substrate binding domain of E.coli DnaK in complex with sheep Bac7(1-21)==
==Crystal structure of the substrate binding domain of E.coli DnaK in complex with sheep Bac7(1-21)==
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<StructureSection load='4jwe' size='340' side='right' caption='[[4jwe]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='4jwe' size='340' side='right'caption='[[4jwe]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jwe]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JWE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jwe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JWE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dkx|1dkx]], [[1dky|1dky]], [[1dkz|1dkz]], [[3dpo|3dpo]], [[3dpp|3dpp]], [[3dpq|3dpq]], [[3qnj|3qnj]], [[4e81|4e81]], [[4jwc|4jwc]], [[4jwd|4jwd]], [[4jwi|4jwi]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jwe OCA], [https://pdbe.org/4jwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jwe RCSB], [https://www.ebi.ac.uk/pdbsum/4jwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jwe ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dnaK, groP, grpF, seg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jwe OCA], [http://pdbe.org/4jwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jwe RCSB], [http://www.ebi.ac.uk/pdbsum/4jwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jwe ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] [[http://www.uniprot.org/uniprot/CTHL3_SHEEP CTHL3_SHEEP]] Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms (By similarity).
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[https://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4jwe" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4jwe" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Straeter, N]]
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[[Category: Large Structures]]
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[[Category: Zahn, M]]
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[[Category: Ovis aries]]
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[[Category: Antimicrobial peptide]]
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[[Category: Straeter N]]
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[[Category: Chaperone]]
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[[Category: Zahn M]]
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[[Category: Chaperone-antibiotic complex]]
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[[Category: Peptide binding]]
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[[Category: Peptide binding protein]]
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Revision as of 11:28, 30 November 2022

Crystal structure of the substrate binding domain of E.coli DnaK in complex with sheep Bac7(1-21)

PDB ID 4jwe

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