1j7e
From Proteopedia
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'''A Structural Basis for the Unique Binding Features of the Human Vitamin D-binding Protein''' | '''A Structural Basis for the Unique Binding Features of the Human Vitamin D-binding Protein''' | ||
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[[Category: Ranter, C De.]] | [[Category: Ranter, C De.]] | ||
[[Category: Verboven, C.]] | [[Category: Verboven, C.]] | ||
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| - | [[Category: | + | [[Category: Group-specific component]] |
| - | [[Category: | + | [[Category: Vitamin d binding]] |
| - | [[Category: | + | [[Category: Vitamin d3 analogue]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:52:39 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:52, 2 May 2008
A Structural Basis for the Unique Binding Features of the Human Vitamin D-binding Protein
Overview
The human serum vitamin D-binding protein (DBP) has many physiologically important functions, ranging from transporting vitamin D3 metabolites, binding and sequestering globular actin and binding fatty acids to functioning in the immune system. Here we report the 2.3 A crystal structure of DBP in complex with 25-hydroxyvitamin D3, a vitamin D3 metabolite, which reveals the vitamin D-binding site in the N-terminal part of domain I. To more explicitly explore this, we also studied the structure of DBP in complex with a vitamin D3 analog. Comparisons with the structure of human serum albumin, another family member, reveal a similar topology but also significant differences in overall, as well as local, folding. These observed structural differences explain the unique vitamin D3-binding property of DBP.
About this Structure
1J7E is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A structural basis for the unique binding features of the human vitamin D-binding protein., Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C, Nat Struct Biol. 2002 Feb;9(2):131-6. PMID:11799400 Page seeded by OCA on Fri May 2 20:52:39 2008
