4k6z

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==The Jak1 kinase domain in complex with compound 37==
==The Jak1 kinase domain in complex with compound 37==
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<StructureSection load='4k6z' size='340' side='right' caption='[[4k6z]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
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<StructureSection load='4k6z' size='340' side='right'caption='[[4k6z]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4k6z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K6Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4k6z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K6Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1Q3:(1R,2S)-2-{[8-OXO-2-(1H-PYRAZOL-4-YL)-5,8-DIHYDROPYRIDO[3,4-D]PYRIMIDIN-4-YL]AMINO}CYCLOPENTANECARBONITRILE'>1Q3</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1Q3:(1R,2S)-2-{[8-OXO-2-(1H-PYRAZOL-4-YL)-5,8-DIHYDROPYRIDO[3,4-D]PYRIMIDIN-4-YL]AMINO}CYCLOPENTANECARBONITRILE'>1Q3</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6z OCA], [https://pdbe.org/4k6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k6z RCSB], [https://www.ebi.ac.uk/pdbsum/4k6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k6z ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">JAK1, JAK1A, JAK1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6z OCA], [http://pdbe.org/4k6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k6z RCSB], [http://www.ebi.ac.uk/pdbsum/4k6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k6z ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
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[https://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Janus kinase|Janus kinase]]
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*[[Janus kinase 3D structures|Janus kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Large Structures]]
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[[Category: Fong, R]]
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[[Category: Fong R]]
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[[Category: Lupardus, P J]]
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[[Category: Lupardus PJ]]
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[[Category: Kinase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Revision as of 11:42, 30 November 2022

The Jak1 kinase domain in complex with compound 37

PDB ID 4k6z

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