This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1j7v
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1j7v.jpg|left|200px]] | [[Image:1j7v.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1j7v", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | | | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | + | --> | |
| - | + | {{STRUCTURE_1j7v| PDB=1j7v | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''HUMAN IL-10 / IL-10R1 COMPLEX''' | '''HUMAN IL-10 / IL-10R1 COMPLEX''' | ||
| Line 29: | Line 26: | ||
[[Category: Walter, M R.]] | [[Category: Walter, M R.]] | ||
[[Category: 4 helix bundle]] | [[Category: 4 helix bundle]] | ||
| - | [[Category: | + | [[Category: Class 2 receptor]] |
| - | [[Category: | + | [[Category: Cytokine receptor complex]] |
| - | [[Category: | + | [[Category: Interleukin-10]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:53:46 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:53, 2 May 2008
HUMAN IL-10 / IL-10R1 COMPLEX
Overview
Interleukin 10 (IL-10) is a dimeric cytokine that plays a central role in suppressing inflammatory responses. These activities are dependent on the interaction of IL-10 with its high-affinity receptor (IL-10R1). This intermediate complex must subsequently recruit the low-affinity IL-10R2 chain before cell signaling can occur. Here we report the 2.9 A crystal structure of IL-10 bound to a soluble form of IL-10R1 (sIL-10R1). The complex consists of two IL-10s and four sIL-10R1 molecules. Several residues in the IL-10/sIL-10R1 interface are conserved in all IL-10 homologs and their receptors. The data suggests that formation of the active IL-10 signaling complex occurs by a novel molecular recognition paradigm where IL-10R1 and IL-10R2 both recognize the same binding site on IL-10.
About this Structure
1J7V is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site., Josephson K, Logsdon NJ, Walter MR, Immunity. 2001 Jul;15(1):35-46. PMID:11485736 Page seeded by OCA on Fri May 2 20:53:46 2008
