1j7v
From Proteopedia
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'''HUMAN IL-10 / IL-10R1 COMPLEX''' | '''HUMAN IL-10 / IL-10R1 COMPLEX''' | ||
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[[Category: Walter, M R.]] | [[Category: Walter, M R.]] | ||
[[Category: 4 helix bundle]] | [[Category: 4 helix bundle]] | ||
| - | [[Category: | + | [[Category: Class 2 receptor]] |
| - | [[Category: | + | [[Category: Cytokine receptor complex]] |
| - | [[Category: | + | [[Category: Interleukin-10]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:53:46 2008'' | |
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Revision as of 17:53, 2 May 2008
HUMAN IL-10 / IL-10R1 COMPLEX
Overview
Interleukin 10 (IL-10) is a dimeric cytokine that plays a central role in suppressing inflammatory responses. These activities are dependent on the interaction of IL-10 with its high-affinity receptor (IL-10R1). This intermediate complex must subsequently recruit the low-affinity IL-10R2 chain before cell signaling can occur. Here we report the 2.9 A crystal structure of IL-10 bound to a soluble form of IL-10R1 (sIL-10R1). The complex consists of two IL-10s and four sIL-10R1 molecules. Several residues in the IL-10/sIL-10R1 interface are conserved in all IL-10 homologs and their receptors. The data suggests that formation of the active IL-10 signaling complex occurs by a novel molecular recognition paradigm where IL-10R1 and IL-10R2 both recognize the same binding site on IL-10.
About this Structure
1J7V is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site., Josephson K, Logsdon NJ, Walter MR, Immunity. 2001 Jul;15(1):35-46. PMID:11485736 Page seeded by OCA on Fri May 2 20:53:46 2008
