1j7x
From Proteopedia
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'''CRYSTAL STRUCTURE OF A FUNCTIONAL UNIT OF INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN (IRBP)''' | '''CRYSTAL STRUCTURE OF A FUNCTIONAL UNIT OF INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN (IRBP)''' | ||
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[[Category: Gonzalez-Fernandez, F.]] | [[Category: Gonzalez-Fernandez, F.]] | ||
[[Category: Loew, A.]] | [[Category: Loew, A.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:53:51 2008'' | |
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Revision as of 17:53, 2 May 2008
CRYSTAL STRUCTURE OF A FUNCTIONAL UNIT OF INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN (IRBP)
Overview
Interphotoreceptor retinoid binding protein (IRBP), the major soluble component of the interphotoreceptor matrix, is critical to the function, integrity, and development of the vertebrate retina. Although its role is poorly understood, IRBP has been thought to protect 11-cis retinal and all-trans retinol while facilitating their exchange between the photoreceptors and retinal-pigmented epithelium. We determined the X-ray structure of one of the functional units, or modules, of Xenopus laevis IRBP to 1.8 A resolution by multiwavelength anomalous dispersion. The monomeric protein consists of two domains separated by a hydrophobic ligand binding site. A structural homology to the recently solved photosystem II D1 C-terminal-processing protease and the enoyl-CoA isomerase/hydratase family suggests the utility of a common fold used in diverse settings, ranging from proteolysis to fatty acid isomerization to retinoid transport.
About this Structure
1J7X is a Single protein structure of sequence from Xenopus laevis. Full crystallographic information is available from OCA.
Reference
Crystal structure of the functional unit of interphotoreceptor retinoid binding protein., Loew A, Gonzalez-Fernandez F, Structure. 2002 Jan;10(1):43-9. PMID:11796109 Page seeded by OCA on Fri May 2 20:53:51 2008
