This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4kfn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors==
==Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors==
-
<StructureSection load='4kfn' size='340' side='right' caption='[[4kfn]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+
<StructureSection load='4kfn' size='340' side='right'caption='[[4kfn]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4kfn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KFN FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4kfn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KFN FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1QR:N-[4-(PIPERIDIN-1-YLSULFONYL)BENZYL]-1H-PYRROLO[3,2-C]PYRIDINE-2-CARBOXAMIDE'>1QR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1QR:N-[4-(PIPERIDIN-1-YLSULFONYL)BENZYL]-1H-PYRROLO[3,2-C]PYRIDINE-2-CARBOXAMIDE'>1QR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jr5|4jr5]], [[4kfo|4kfo]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kfn OCA], [https://pdbe.org/4kfn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kfn RCSB], [https://www.ebi.ac.uk/pdbsum/4kfn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kfn ProSAT]</span></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NAMPT, PBEF, PBEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kfn OCA], [http://pdbe.org/4kfn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kfn RCSB], [http://www.ebi.ac.uk/pdbsum/4kfn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kfn ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
+
[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 20:
==See Also==
==See Also==
-
*[[Phosphoribosyltransferase|Phosphoribosyltransferase]]
+
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Nicotinamide phosphoribosyltransferase]]
+
[[Category: Large Structures]]
-
[[Category: Bair, K W]]
+
[[Category: Bair KW]]
-
[[Category: Bauer, P]]
+
[[Category: Bauer P]]
-
[[Category: Baumeister, T]]
+
[[Category: Baumeister T]]
-
[[Category: Brien, T O]]
+
[[Category: Buckmelter AJ]]
-
[[Category: Buckmelter, A J]]
+
[[Category: Caligiuri M]]
-
[[Category: Caligiuri, M]]
+
[[Category: Clodfelter KH]]
-
[[Category: Clodfelter, K H]]
+
[[Category: Dragovich PS]]
-
[[Category: Dragovich, P S]]
+
[[Category: Gunzner-Toste J]]
-
[[Category: Gunzner-Toste, J]]
+
[[Category: Han B]]
-
[[Category: Han, B]]
+
[[Category: Ho Y]]
-
[[Category: Ho, Y]]
+
[[Category: Kley N]]
-
[[Category: Kley, N]]
+
[[Category: Liederer BM]]
-
[[Category: Liederer, B M]]
+
[[Category: Lin J]]
-
[[Category: Lin, J]]
+
[[Category: Ly J]]
-
[[Category: Ly, J]]
+
[[Category: O'Brien T]]
-
[[Category: Oh, A]]
+
[[Category: Oh A]]
-
[[Category: Reynolds, D J]]
+
[[Category: Reynolds DJ]]
-
[[Category: Sharma, G]]
+
[[Category: Sharma G]]
-
[[Category: Smith, C C]]
+
[[Category: Smith CC]]
-
[[Category: Wang, L]]
+
[[Category: Wang L]]
-
[[Category: Wang, W]]
+
[[Category: Wang W]]
-
[[Category: Wang, Z]]
+
[[Category: Wang Z]]
-
[[Category: Xiao, Y]]
+
[[Category: Xiao Y]]
-
[[Category: Yuen, P]]
+
[[Category: Yuen P]]
-
[[Category: Zak, M]]
+
[[Category: Zak M]]
-
[[Category: Zhao, G]]
+
[[Category: Zhao G]]
-
[[Category: Zheng, X]]
+
[[Category: Zheng X]]
-
[[Category: Transferase-transferase inhibitor complex]]
+

Revision as of 11:56, 30 November 2022

Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

PDB ID 4kfn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4kfn"
Personal tools