4khm

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==HCV NS5B GT1A with GSK5852==
==HCV NS5B GT1A with GSK5852==
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<StructureSection load='4khm' size='340' side='right' caption='[[4khm]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4khm' size='340' side='right'caption='[[4khm]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4khm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1a Hepatitis c virus subtype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KHM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4khm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KHM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PV:[4-({[5-CYCLOPROPYL-2-(4-FLUOROPHENYL)-3-(METHYLCARBAMOYL)-1-BENZOFURAN-6-YL](METHYLSULFONYL)AMINO}METHYL)-2-FLUOROPHENYL]BORONIC+ACID'>1PV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PV:[4-({[5-CYCLOPROPYL-2-(4-FLUOROPHENYL)-3-(METHYLCARBAMOYL)-1-BENZOFURAN-6-YL](METHYLSULFONYL)AMINO}METHYL)-2-FLUOROPHENYL]BORONIC+ACID'>1PV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kai|4kai]], [[4kb7|4kb7]], [[4kbi|4kbi]], [[4ke5|4ke5]], [[4khr|4khr]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4khm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4khm OCA], [https://pdbe.org/4khm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4khm RCSB], [https://www.ebi.ac.uk/pdbsum/4khm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4khm ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31646 Hepatitis C virus subtype 1a])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4khm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4khm OCA], [http://pdbe.org/4khm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4khm RCSB], [http://www.ebi.ac.uk/pdbsum/4khm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4khm ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B1PPP0_9HEPC B1PPP0_9HEPC]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hepatitis c virus subtype 1a]]
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[[Category: Hepatitis C virus genotype 1a]]
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Large Structures]]
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[[Category: Kahler, K M]]
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[[Category: Kahler KM]]
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[[Category: Shotwell, J B]]
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[[Category: Shotwell JB]]
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[[Category: Williams, S P]]
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[[Category: Williams SP]]
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[[Category: Boron]]
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[[Category: Hcv ns5b]]
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[[Category: Hcv polymerase]]
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[[Category: P66]]
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[[Category: P70]]
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[[Category: Replication-replication inhibitor complex]]
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[[Category: Rna dependent rna polymerase]]
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[[Category: Rna directed rna polymerase]]
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[[Category: Site iv inhibitor]]
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Revision as of 11:58, 30 November 2022

HCV NS5B GT1A with GSK5852

PDB ID 4khm

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