7u4i

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'''Unreleased structure'''
 
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The entry 7u4i is ON HOLD until Paper Publication
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==Crystal structure of human GPX4-U46C-R152H in complex with CDS9==
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<StructureSection load='7u4i' size='340' side='right'caption='[[7u4i]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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Authors: Forouhar, F., Liu, H., Lin, A.J., Wang, Q., Xia, X., Stockwell, B.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7u4i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U4I FirstGlance]. <br>
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Description: Crystal structure of human GPX4-U46C-R152H in complex with CDS9
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L9U:2-bromo-N-[(thiophen-2-yl)methyl]acetamide'>L9U</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u4i OCA], [https://pdbe.org/7u4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u4i RCSB], [https://www.ebi.ac.uk/pdbsum/7u4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u4i ProSAT]</span></td></tr>
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[[Category: Forouhar, F]]
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</table>
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[[Category: Wang, Q]]
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== Function ==
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[[Category: Lin, A.J]]
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[https://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
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[[Category: Xia, X]]
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__TOC__
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[[Category: Liu, H]]
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</StructureSection>
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[[Category: Stockwell, B.R]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Forouhar F]]
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[[Category: Lin AJ]]
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[[Category: Liu H]]
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[[Category: Polychronidou V]]
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[[Category: Soni RK]]
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[[Category: Stockwell BR]]
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[[Category: Wang Q]]
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[[Category: Xia X]]

Revision as of 08:12, 7 December 2022

Crystal structure of human GPX4-U46C-R152H in complex with CDS9

PDB ID 7u4i

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